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Prolonged retrograde amnesia following sedation with propofol in a 12-year-old boy.

Quraishi SA, Girdharry TD, Xu SG, Orkin FK

Division of Pediatric Neurology, Department of Anesthesiology, Pennsylvania State University College of Medicine, Hershey, PA, USA. squraishi@psu.edu

Propofol is commonly used for sedation in a variety of clinical settings, as well as for induction and maintenance of anesthesia. The ease with which propofol can be administered and titrated to clinical effect, in addition to its accepted safety profile, has made it the drug of choice for sedation in outpatient procedures, such as gastrointestinal endoscopy. While short-term amnesia is a well-known side-effect of propofol, we present the first documented case of prolonged retrograde amnesia following propofol administration in a pediatric patient. Possible mechanisms and clinical management strategies related to this unique event are discussed.

Published 15 March 2007 in Paediatr Anaesth, 17(4): 375-9.
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